An All-Inclusive Guide to Mastering 51 Rummy 51 Rummy is an engaging card game that blends skill, strategy, and a degree of chance. Usually two to six players use a standard 52-card deck to plslots all appay the game. Making valid sets and runs—card combinations that satisfy certain requirements—is the goal. While a run is a series of three or more cards in the same suit, a set is made up of three or four cards of the same rank. The goal is to combine their hands into legitimate combinations while reducing the number of points remaining in their hands when another player goes out.